Research Assistant Professor

Department of Neuroscience & Experimental Therapeutics
Medical Research and Education Building
aselvamani@medicine.tamhsc.edu

Education and Training

  • MS in Molecular Biology, University of Madras, India
  • PhD in Molecular Biology (Neuroscience), Texas Women’s University (Federation Program), Texas
  • Postdoctoral Fellow, Department of Neuroscience and Experimental Therapeutics, Texas A&M University
  • Associate Research Scientist, Department of Neuroscience and Experimental Therapeutics, Texas A&M University

Research Interests

My research focuses primarily on IGF-1 and microRNA’s (miRNA’s) role in Stroke and their potential role as therapeutics post stroke. I have used miRNA profiling studies to assist discover various expression levels of post-stroke miRNA, stratified by age and sex. Additionally, my expertise lies in, in vivo miRNA delivery, miRNA profiling studies in circulation and brain tissue, biostatistical analysis, in situ hybridizations and animal behavioral assays. In order to better understand the sexual dimorphisms that underlie stroke pathophysiology, most of my research has included both females and males to evaluate the severity of stroke, effect of miRNA treatment or mechanisms underlying neuroprotection.

Other research intererests in the recent past have also included understanding the effect of stroke on alcohol intake and ow shift work affects pathological outcomes following stroke. In my short and long-term future, I would like to focus my research towards women’s health issues especially towards a) Stroke related neuronal injury and functional impairment in the aging and aged females b) Mechanistic differences underlying sexual dimorphism in miRNA treatment and c) Potential therapeutic intervention post-stroke.

Selected Publications

  • Selvamani Aand Sohrabji F. (2017). MiR-363 improves stroke outcome in females but not male rats. Int. Jul; 107:168-181. PMCID: PMC5398946.
  • Selvamani A, Williams MH, Miranda RC, Sohrabji F. (2014). Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model. Clinic Science (Lond), 127:77-89. PMCID: PMC4386587.
  • Selvamani A, Sathyan P, Miranda RC, and Sohrabji F. (2012). An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model. PLoS One, 7(2):e32662. PMCID: PMC3290559.
  • Selvamani Aand Sohrabji F. (2010). Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats. Neurobiology of Aging, 31:1618-1628. PMCID: PMC2909345.
  • Selvamani Aand Sohrabji F. (2010). The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1. Journal of Neuroscience, 30:6852-6861. PMCID: PMC2887690.

 

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